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Design and development of metallic biomaterials with biological and mechanical biocompatibility
Author(s) -
Niinomi Mitsuo
Publication year - 2019
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36667
Subject(s) - materials science , biocompatibility , biocompatible material , ceramic , compatibility (geochemistry) , nanotechnology , biomaterial , composite material , biomedical engineering , metallurgy , medicine
In the present article, the recent trends in the research and development of metallic biomaterials are discussed with focus on the results obtained by the author's group. The design of biocompatible metallic biomaterials possessing excellent biological and mechanical properties, including titanium alloys with low Young's modulus, is reviewed with focus on Young's modulus, fatigue strength, and peculiar behavior. The evaluation of biological compatibility including cell viability and living tissue compatibility using animal models and surface modifications using bioactive ceramic and blood‐compatible polymers are summarized. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 944–954, 2019.