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Engineered pH‐responsive hydrazone‐carboxylate complexes‐encapsulated 2D matrices for cathepsin‐mediated apoptosis in cancer
Author(s) -
Liu ChenGuang,
Kankala Ranjith Kumar,
Liao HongYue,
Chen AiZheng,
Wang ShiBin
Publication year - 2019
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36610
Subject(s) - materials science , nanoparticle , drug delivery , carboxylate , doxorubicin , cancer cell , nanotechnology , cathepsin , hydroxide , hydrazone , combinatorial chemistry , biophysics , cancer , biochemistry , organic chemistry , chemotherapy , chemistry , biology , enzyme , genetics
Spurred by the current advancements in engineering various intelligent nanoparticle‐based drug delivery systems, conjugation of drugs with the stimuli‐responsive molecular switches has become one of the most efficient approaches to deliver a drug cargo in spatiotemporal controlled fashions. In this study, we fabricated an innovative pH‐triggered hydrazone‐carboxylate complex of doxorubicin (Dox), which was subsequently encapsulated in the layered double hydroxide (LDH) nanoparticles for effective cancer therapeutics. These two‐dimensional (2D) biodegradable matrices efficiently delivered Dox by pH‐triggered release in the acidic lysosomal environment and their subsequent escape to cytosol. Moreover, the delivered Dox molecules and high positively‐charged surfaces of LDHs facilitated the cancer cell ablation via enhancing the cathepsins‐mediated cell apoptosis assisted by free radical species generation. The critical advancements in the nanoparticle‐based designs and substantial ablation of tumor cells through a free radical attack indicate that the designed pH‐triggered drug composites can be used for efficient cancer therapeutics. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1184–1194, 2019.