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Comparison of catheter thrombogenicity in a modified chandler loop model using goat blood
Author(s) -
Olsen Aaron L.,
Long Michael
Publication year - 2018
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36509
Subject(s) - thrombogenicity , catheter , biomedical engineering , materials science , in vivo , silicone , in vitro , surgery , platelet , medicine , biology , composite material , microbiology and biotechnology , biochemistry
Thrombogenicity testing is a key component in the development of medical devices intended for contact with blood. The Chandler loop system has previously been used as an in vitro thrombogenicity testing method. In this study, we used a modified version of the Chandler loop model to evaluate its capacity to detect differential thrombogenic potential of different catheter materials using goat blood. We also sought to determine the optimal experimental conditions for detecting the thrombogenicity of catheter material. Using the Chandler loop system with goat blood we demonstrated that silicone catheters had a stronger thrombogenicity as compared to polyurethane catheters as evidenced by significantly larger thrombi ( p < 0.001) and higher infusion pressures ( p < 0.05). This is consistent with many, but not all, previous in vitro and in vivo studies comparing polyurethane to silicone catheters. The use of this modified Chandler loop system with goat blood may provide an additional in vitro testing platform for thrombogenicity testing of catheters. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3143–3151, 2018.