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Acid‐triggered synergistic chemo‐photodynamic therapy systems based on metal‐coordinated supramolecular interaction
Author(s) -
Wang Jinze,
Liu Lin,
Yin Liping,
Chen Li
Publication year - 2018
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36484
Subject(s) - photosensitizer , porphyrin , hela , photodynamic therapy , supramolecular chemistry , materials science , histidine , drug delivery , in vivo , combinatorial chemistry , biophysics , chemistry , nanotechnology , biochemistry , in vitro , photochemistry , organic chemistry , amino acid , molecule , biology , microbiology and biotechnology
To enhance anticancer efficacy and decrease side effects, the synergistic multi‐agent therapy has now increasingly gotten great attention. Herein, the flexible polycaprolactone had been modified by histidine and formed assembles with PEGylated metallo‐porphyrin via metal‐coordinated supramolecular interaction. This supramolecular assembles showed excellent acid sensitivity. At neutral environment, the hydrophobic anticancer drug could be effectively co‐encapsulated with photosensitizer Fe‐TPP to improve the water solubility. While at the intracellular microenvironment, the changed acid environment would trigger the drug and Fe‐TPP release due to the reduction of metal‐coordinated interaction between histidine and metallo‐porphyrin leading to the disintegration of assembles. The in vivo anticancer experiments toward HeLa and MCF‐7 cells disclosed that this co‐delivery system of anticancer drug and photosensitizer showed enhanced anticancer efficacy, implying that the synergistic chemo‐photodynamic therapy could improve cellular proliferation inhibition. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2955–2962, 2018.