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Evaluation of a polyvinyl alcohol‐alginate based hydrogel for precise 3D bioprinting
Author(s) -
Yu Fei,
Han Xiao,
Zhang Kaijia,
Dai Bingyang,
Shen Sheng,
Gao Xiang,
Teng Huajian,
Wang Xingsong,
Li Lan,
Ju Huangxian,
Wang Wei,
Zhang Junfeng,
Jiang Qing
Publication year - 2018
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36483
Subject(s) - polyvinyl alcohol , materials science , 3d bioprinting , scanning electron microscope , composite material , rapid prototyping , rheology , rheometer , biomedical engineering , tissue engineering , medicine
In this study, we designed a polyvinyl alcohol (PVA)‐alginate based hydrogel and evaluated its cytocompatibility and printability. The samples were fabricated by 3D printing using a freeze–thaw process. The scanning electron microscope, material testing machine, rheometer, and cell counting kit‐8 assay were used to examine the morphology, mechanical properties, rheological properties, and cytocompatiblity of the scaffolds, respectively. The mechanical strength, cytocompatiblity, crosslinking time, and printability were remarkably improved with the use of PVA. To sum up, our data suggest that hybrid bio‐ink is more appropriate for precise 3D bioprinting due to its rapid prototyping capability and better cytocompatibility. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2944–2954, 2018.