Premium
Optimization of PLGA formulation containing protein or peptide‐based antigen: Recent advances
Author(s) -
Hajavi Jafar,
Ebrahimian Mahboubeh,
Sankian Mojtaba,
Khakzad Mohammad Reza,
Hashemi Maryam
Publication year - 2018
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36423
Subject(s) - plga , materials science , peptide , glycolic acid , nanotechnology , antigen , particle size , nanoparticle , chemical engineering , lactic acid , biochemistry , chemistry , immunology , biology , engineering , bacteria , genetics
Protein or peptide‐based antigens are the most promising forms to generate custom protective immune responses for clinical applications. Over the last decades, poly(lactic‐co‐glycolic acid) (PLGA) as a biodegradable polymer has gained more attention for delivery of protein and peptide. Besides many appropriate characteristics, to improve its properties to overcome some obstacles such as release profile and it is important instability of antigen during both encapsulation and storage. Therefore, optimized procedures conditions require to be used to maintain the integrity of protein structure under several stress factors in formulation process. In this review article, the properties of PLGA particles, their preparation techniques and strategies for improvement of protein stability during encapsulation into PLGA, release from particle and storage as well as stabilization approaches were summarized. © 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part A: 106A: 2540–2551, 2018