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Development of electrospun poly (vinyl alcohol)‐based bionanocomposite scaffolds for bone tissue engineering
Author(s) -
Enayati Mohammad Saied,
Behzad Tayebeh,
Sajkiewicz Pawel,
Rafienia Mohammad,
Bagheri Rouhollah,
GhasemiMobarakeh Laleh,
Kolbuk Dorota,
Pahlevanneshan Zari,
Bonakdar Shahin H.
Publication year - 2018
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36309
Subject(s) - vinyl alcohol , materials science , nanofiber , simulated body fluid , tissue engineering , ultimate tensile strength , electrospinning , apatite , composite material , porosity , scaffold , contact angle , cellulose , chemical engineering , biomedical engineering , polymer , scanning electron microscope , medicine , engineering
The article is focused on the role of nanohydroxy apatite (nHAp) and cellulose nanofibers (CNFs) as fillers in the electrospun poly (vinyl alcohol) (ES‐PVA) nanofibers for bone tissue engineering (TE). Fibrous scaffolds of PVA, PVA/nHAp (10 wt.%), and PVA/nHAp(10 wt.%)/CNF(3 wt.%) were successfully fabricated and characterized. Tensile test on electrospun PVA/nHAp10 and PVA/nHAp10/CNF3 revealed a three‐fold and seven‐fold increase in modulus compared with pure ES‐PVA (45.45 ± 4.77). Although, nanofiller loading slightly reduced the porosity percentage, all scaffolds had porosity higher than 70%. In addition, contact angle test proved the great hydrophilicity of scaffolds. The presence of fillers reduced in vitro biodegradation rate in PBS while accelerates biomineralization in simulated body fluid (SBF). Furthermore, cell viability, cell attachment, and functional activity of osteoblast MG‐63 cells were studied on scaffolds showing higher cellular activity for scaffolds with nanofillers. Generally, the obtained results confirm that the 3‐componemnt fibrous scaffold of PVA/nHAp/CNF has promising potential in hard TE. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1111–1120, 2018.