Premium
Increased affinity of endothelial cells to NiTi using ultraviolet irradiation: An in vitro study
Author(s) -
Tateshima Satoshi,
Kaneko Naoki,
Yamada Masahiro,
Duckwiler Gary,
Vinuela Fernando,
Ogawa Takahiro
Publication year - 2018
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36304
Subject(s) - nickel titanium , biocompatibility , materials science , irradiation , pseudoelasticity , biomedical engineering , endothelial stem cell , ultraviolet , in vitro , biophysics , shape memory alloy , metallurgy , medicine , microstructure , biochemistry , chemistry , optoelectronics , biology , martensite , physics , nuclear physics
Nickel–titanium alloy (NiTi) is one of the most popular materials used endovascularly because of its shape memory and superelasticity. The NiTi device needs to be covered by endothelial cells after being placed in the blood vessel to reduce ischemic complications. The objective of this study was to examine the impact of ultraviolet (UV) irradiation on the biocompatibility of NiTi surfaces with endothelial cells. NiTi sheets were treated with UV irradiation for 48 h and human aorta derived endothelial cells were used in this study. UV irradiation converted the NiTi surface to hydrophilic state and increased albumin adsorption. The number of endothelial cell migration, attachment, proliferation as well as their metabolic activity were significantly increased on UV treated NiTi. This study provides the first evidence of the photoactivation of NiTi surfaces by UV irradiation and demonstrates improved biocompatibility of UV‐treated NiTi surfaces with vascular endothelial cells. These results suggest that UV irradiation may promote endothelialization of NiTi devices in blood vessels. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1034–1038, 2018.