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One pot synthesis of new poly(vinyl alcohol) blended natural polymer based magnetic hydrogel beads: Controlled natural anticancer alkaloid delivery system
Author(s) -
Kesavan Mookkandi Palsamy,
Ayyanaar Srinivasan,
Lenin Nayagam,
Sankarganesh Murugesan,
Dhaveethu Raja Jeyaraj,
Rajesh Jegathalaprathaban
Publication year - 2018
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36262
Subject(s) - vinyl alcohol , materials science , fourier transform infrared spectroscopy , chitosan , polymer , swelling , self healing hydrogels , chemical engineering , polyethylene glycol , magnetic nanoparticles , nuclear chemistry , drug delivery , polymer chemistry , nanoparticle , composite material , nanotechnology , chemistry , engineering
Facile one‐pot synthesis has been demonstrated for new biocompatible and dual responsive magnetic iron oxide nanoparticles cross‐linked poly(vinyl alcohol) (PVA) blended natural polymer chitosan (CS) based hydrogel beads (mCS‐PVA) as a controlled natural anticancer alkaloid Luotonin A (LuA) delivery system. The prepared magnetic hydrogel beads were characterized using powder X‐ray diffraction measurement, Fourier transform‐infrared spectroscopy, scanning electron microscopy, energy dispersive X‐ray spectroscopy, and vibrating sample magnetometer. The magnetic hydrogel beads are exhibited significant water retention and follow the second order kinetic model in swelling study. The swelling ratio of the magnetic gel beads increased by the addition of PVA and showed a maximum swelling ratio of 40.83 ± 1.01 g/g and follows non‐Fickian water transport mechanism. Stimuli responsive mCS and mCS‐PVA hydrogel beads functionalized with LuA is demonstrated for controlled release at physiological pH and under magnetic field. The magnetic hydrogel beads show highest LuA releasing efficacy at acidic medium (pH = 5.0) with maximum efficiency of 73.33 ± 1.44%. This efficacy may also be tuned by altering the external magnetic field as well as the weight percentage (wt %) of polyethylene glycol. It is clearly that the newly produced magnetic hydrogel beads can be served as an effective intestinal LuA delivery system. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 543–551, 2018.