Premium
Hyaluronic acid‐hydroxyapatite nanocomposite hydrogels for enhanced biophysical and biological performance in a dermal matrix
Author(s) -
Jeong SeolHa,
Fan Yingfang,
Cheon KwangHee,
Baek Jaeuk,
Kim Sukwha,
Kim HyounEe
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36190
Subject(s) - materials science , hyaluronic acid , biomedical engineering , self healing hydrogels , nanocomposite , elastin , composite number , wrinkle , tissue engineering , soft tissue , composite material , matrix (chemical analysis) , polymer chemistry , surgery , medicine , anatomy , pathology
A hyaluronic acid (HAc)‐hydroxyapatite (HAp) nanocomposite (HAc‐nanoHAp) hydrogel was fabricated through an in situ precipitation process for mechanical and biological enhancement as a soft tissue augmentation product. In this study, these composite hydrogel fillers were analyzed from three different perspectives and compared with pure HAc hydrogel for soft tissue augmentation application: (1) rheological behaviors, (2) in vivo lateral diffusion under mouse skin, and (3) wrinkle improvement in a photo‐aged mouse model. HAc‐nanoHAp provided great improvement to wrinkles because of its higher stiffness and gel cohesiveness in comparison with that of pure HAc. HAc‐nanoHAp also presented great enhancement in strengthening the dermal matrix by stimulating the synthesis of collagen and elastin. Thus, HAc‐nanoHAp filler has great potential as a soft tissue augmentation product, improving the biophysical and biological performance in skin tissue. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3315–3325, 2017.