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Fabrication of in situ polymerized poly(butylene succinate‐co‐ethylene terephthalate)/hydroxyapatite nanocomposite to fibrous scaffolds for enhancement of osteogenesis
Author(s) -
Shirali Hadi,
Rafizadeh Mehdi,
Afshar Taromi Faramarz,
Jabbari Esmaiel
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36115
Subject(s) - materials science , nanocomposite , electrospinning , nanofiber , composite material , nanoparticle , crystallinity , polymer , scanning electron microscope , ultimate tensile strength , in situ polymerization , chemical engineering , polymerization , nanotechnology , engineering
A combination of elastic poly(butylene succinate‐co‐ethylene terephthalate) and rigid nano‐hydroxyapatite were used to prepare an in‐situ synthesized nanocomposite mimicing bone structure. The microstructure, morphology, and dispersion of nanoparticles in the nanocomposites were studied using proton nuclear magnetic resonance ( 1 HNMR), scanning electron microscope (SEM), and transmission electron microscopy (TEM), respectively. Then, electrospinning method was used to produce nanofiber matrix with lowest fiber diameter. Presence of chemical bonds among nanoparticles and polymer leads to the excellent particle dispersion and solution phase stability. SEM results show that continuous and bead‐free nanofibers were produced and incorporating nanoparticle slightly increased fibers diameter. Elastic modulus, tensile strength, crystallinity, hydrophilicity and hydrolytic degradability of resulted nanofiber increased with nanoparticle but elongation at break slightly decreased. Proliferation and osteogenic differentiation of human mesenchymal stem cell significantly improved by introducing nanoparticle which indicate that electrospun nanofibers could be used as scaffolds for bone tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2622–2631, 2017.