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Graphene as multifunctional delivery platform in cancer therapy
Author(s) -
Nejabat Mojgan,
Charbgoo Fahimeh,
Ramezani Mohammad
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36080
Subject(s) - graphene , materials science , drug delivery , nanotechnology , biocompatible material , cancer therapy , nanomaterials , delivery system , gene delivery , cancer treatment , cancer , biomedical engineering , genetic enhancement , medicine , gene , biochemistry , chemistry
The biomedical applications of graphene‐based nanomaterials including drug and gene delivery have grown rapidly in the past few years. This is due to its high surface area that results in high cargo loading capacity. It is demonstrated that graphene can improve drug efficacy without increasing the dose of the chemotherapeutic agent in cancer treatment. Considering these valuable benefits of graphene, this review focused on the newest advancements in drug and gene delivery systems using graphene and unveiling advantages and disadvantages of different graphene‐based materials in introducing an effective cargo delivery system for cancer therapy. Different approaches for reducing cytotoxic impacts of graphene oxide and production of biocompatible delivery platform were also reviewed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2355–2367, 2017.