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Silicates in orthopedics and bone tissue engineering materials
Author(s) -
Zhou Xianfeng,
Zhang Nianli,
Mankoci Steven,
Sahai Nita
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36061
Subject(s) - silicate , materials science , tissue engineering , silicate glass , biomedical engineering , nanotechnology , chemical engineering , composite material , engineering
Following the success of silicate‐based glasses as bioactive materials, silicates are believed to play important roles in promoting bone formation and have therefore been considered to provide a hydroxyapatite (HAP) surface layer capable of binding to bone as well as potentially being a pro‐osteoinductive factor. Natural silicate minerals and silicate‐substituted HAPs are also being actively investigated as orthopaedic bone and dental biomaterials for application in tissue engineering. However, the mechanisms for the proposed roles of silicate in these materials have not been fully understood and are controversial. Here, we review the potential roles of silicate for bone tissue engineering applications and recent breakthroughs in identifying the cellular‐level molecular mechanisms for the osteoinductivity of silica. The goal of this article is to inspire new ideas for the rational design of third‐generation cell‐and gene‐affecting biomaterials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2090–2102, 2017.