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Influence of designer self‐assembling nanofiber scaffolds containing anti‐cancer peptide motif on hepatoma carcinoma cells
Author(s) -
Liu Ting,
Li Pindong,
Jin Honglin,
Ding Qian,
Zou Zhenwei,
Peng Gang
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36059
Subject(s) - self assembling peptide , materials science , nanofiber , scaffold , peptide , cancer cell , rgd motif , nanotechnology , adhesion , cell adhesion , cancer research , cancer , biomedical engineering , chemistry , biochemistry , biology , medicine , composite material
Nanotechnology provides a novel scope for cancer therapeutics. Nanoscale platforms could influence the survival, adhesion, and migration of cancer cells through altering the tumor microenvironments. We report here the development of an anti‐tumor material designed specifically for cancer therapy. We synthesized a 48‐amino acid peptide RADA‐KLA, which could self‐assemble into nanostructures with antitumor activities. We tested the microstructure of RADA‐KLA nanofiber scaffold using transmission electron microscopy (TEM) and accessed rheological properties of the material. Then, we demonstrated the effects of RADA‐KLA nanofibers on hepatoma carcinoma cells. We found that RADA‐KLA self‐assembling peptide scaffold could induce cell death, and inhibit adhesion and migration of hepatoma carcinoma cells. Our results indicate that the designer peptide scaffold has anti‐tumor activities and could be used for cancer therapy. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2329–2334, 2017.