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The progress and challenges for dermal regeneration in tissue engineering
Author(s) -
Zhou Hanlei,
You Chuangang,
Wang Xingang,
Jin Ronghua,
Wu Pan,
Li Qiong,
Han Chunmao
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35996
Subject(s) - regeneration (biology) , dermis , extracellular matrix , epidermis (zoology) , scars , wound healing , materials science , skin repair , transplantation , tissue engineering , process (computing) , anatomy , biomedical engineering , microbiology and biotechnology , pathology , medicine , biology , surgery , computer science , operating system
Wound healing is an inherent response resulting in the restoration of tissue integrity. It is a complex process involving cell migration, proliferation, differentiation, apoptosis, and the synthesis and remodeling of the extracellular matrix (ECM). The dermal tissue is an important component of skin that acts as a connecting link between the epidermis and hypodermis. The appearance of scars and contractures after autologous split‐thickness skin transplantation or single epidermis diaphragm transplantation for full skin defects indicates that the dermal tissue plays an important role in skin regeneration. Theoretically, dermis cannot regenerate like the liver, bone and epidermis after being destroyed by burns or avulsion. Scarring is hard to avoid during the process of natural healing. However, if the dermis could be reconstructed perfectly, this would be a breakthrough in the methods used for wound healing. In this review, we summarize recent research about dermal regeneration and discuss the probability of advances in the field. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1208–1218, 2017.