Premium
Osteoblast response to the surface topography of hydroxyapatite two‐dimensional films
Author(s) -
Yang Gai,
Liu Zili,
Guo Yuming,
Zhang Jie,
Li Han,
Shi Weike,
Feng Jing,
Wang Kui,
Yang Lin
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35967
Subject(s) - materials science , polylactic acid , wetting , osteoblast , surface roughness , surface finish , adsorption , composite material , chemical engineering , nanotechnology , organic chemistry , polymer , in vitro , biochemistry , chemistry , engineering
In the current study, three hydroxyapatite two‐dimensional films with similar wettability but different topological roughness have been prepared through a facile one‐step method using hydrated polylactic acid discs as substrates. The results indicated that the protein adsorption capabilities of the hydroxyapatite two‐dimensional films and the proliferation of osteoblast cells on the as‐prepared films increased obviously with the increase of the films' roughness. These reveal that the cellular responses to two‐dimensional materials can be efficiently tuned by easily adjusting the topological roughness. This finding affords an efficient strategy to regulate the cellular response to bioinorganic two‐dimensional materials and significantly expanded their application potentials in tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 991–999, 2017.