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Osteogenic activity and antibacterial effect of porous titanium modified with metal‐organic framework films
Author(s) -
Chen Junyu,
Zhang Xin,
Huang Chao,
Cai He,
Hu Shanshan,
Wan Qianbing,
Pei Xibo,
Wang Jian
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35960
Subject(s) - materials science , titanium , porosity , metal , composite material , chemical engineering , nanotechnology , metallurgy , engineering
As a new class of crystalline nanoporous materials, metal‐organic frameworks (MOFs) have recently been used for biomedical applications due to their large surface area, high porosity, and theoretically infinite structures. To improve the biological performance of titanium, MOF films were applied to surface modification of titanium. Zn‐based MOF films composed of zeolitic imidazolate framework‐8 (ZIF‐8) crystals with nanoscale and microscale sizes (nanoZIF‐8 and microZIF‐8) were prepared on porous titanium surfaces by hydrothermal and solvothermal methods, respectively. The ZIF‐8 films were characterized by powder X‐ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The nanoZIF‐8 film exhibited good biocompatibility, whereas the microZIF‐8 film showed obvious cytotoxicity to MG63 cells. Compared to pure titanium and alkali‐ and heat‐treated porous titanium, the nanoZIF‐8 film not only enhanced alkaline phosphatase (ALP) activity, extracellular matrix mineralization, and expression of osteogenic genes (ALP, Runx2) in MG63 cells but also inhibited the growth of Streptococcus mutans . These results indicate that MOF films or coatings may be promising candidates for bone tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 834–846, 2017.