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Nacre, a natural, multi‐use, and timely biomaterial for bone graft substitution
Author(s) -
Zhang Ganggang,
Brion Alice,
Willemin AnneSophie,
Piet MarieHélène,
Moby Vanessa,
Bianchi Arnaud,
Mainard Didier,
Galois Laurent,
Gillet Pierre,
Rousseau Marthe
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35939
Subject(s) - biomaterial , materials science , biocompatible material , biomedical engineering , nanotechnology , medicine
During the past two decades, with a huge and rapidly increasing clinical need for bone regeneration and repair, bone substitutes are more and more seen as a potential solution. Major innovation efforts are being made to develop such substitutes, some having advanced even to clinical practice. It is now time to turn to natural biomaterials. Nacre, or mother‐of‐pearl, is an organic matrix‐calcium carbonate coupled shell structure produced by molluscs. In vivo and in vitro studies have revealed that nacre is osteoinductive, osteoconductive, biocompatible, and biodegradable. With many other outstanding qualities, nacre represents a natural and multi‐use biomaterial as a bone graft substitute. This review aims at summarising the current needs in orthopaedic clinics and the challenges for the development of bone substitutes; most of all, we systematically review the physiological characteristics and biological evidence of nacre's effects centred on osteogenesis, and finally we put forward the potential use of nacre as a bone graft substitute. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 662–671, 2017.