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3D printing of PLGA scaffolds for tissue engineering
Author(s) -
Mironov Anton V.,
Grigoryev Aleksey M.,
Krotova Larisa I.,
Skaletsky Nikolaj N.,
Popov Vladimir K.,
Sevastianov Viktor I.
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35871
Subject(s) - materials science , tissue engineering , biomedical engineering , extrusion , plga , adipose tissue , mesenchymal stem cell , adhesive , matrix (chemical analysis) , nanotechnology , composite material , microbiology and biotechnology , nanoparticle , biology , biochemistry , medicine , layer (electronics)
We proposed a novel method of generation of bioresorbable polymeric scaffolds with specified architectonics for tissue engineering using extrusion three‐dimensional (3D) printing with solutions of polylactoglycolide in tetraglycol with their subsequent solidifying in aqueous medium. On the basis of 3D computer models, we obtained the matrix structures with interconnected system of pores ranging in size from 0.5 to 500 µm. The results of in vitro studies using cultures of line NIH 3Т3 mouse fibroblasts, floating islet cultures of newborn rabbit pancreas, and mesenchymal stem cells of human adipose tissue demonstrated the absence of cytotoxicity and good adhesive properties of scaffolds in regard to the cell cultures chosen. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 104–109, 2017.