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Vaterite coatings on electrospun polymeric fibers for biomedical applications
Author(s) -
Savelyeva Maria S.,
Abalymov Anatoly A.,
Lyubun German P.,
Vidyasheva Irina V.,
Yashchenok Alexey M.,
Douglas Timothy E. L.,
Gorin Dmitry A.,
Parakhonskiy Bogdan V.
Publication year - 2017
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35870
Subject(s) - vaterite , materials science , biomineralization , calcium carbonate , electrospinning , nanoparticle , chemical engineering , porosity , simulated body fluid , drug delivery , composite material , coating , biomedical engineering , nanotechnology , polymer , scanning electron microscope , medicine , engineering , aragonite
The process of porous calcium carbonate (CaCO 3 ) covering on electrospun poly(ε‐caprolactone) (PCL) fibers is described in this study. Uniform CaCO 3 coatings, composed of vaterite microparticles and its aggregates, were formed on PCL fibers by mineral precipitation from solution under ultrasonic treatment. The porous structure of CaCO 3 in vaterite polymorphic form is useful for loading of various substances (drugs and nanoparticles), and this property makes vaterite an appropriate material for design of drug delivery systems. Such mineralization was implemented to attain therapeutic and/or biological activity of tissue engineering scaffolds based on electrospun PCL, by means of CaCO 3 coatings. Various structures and polymorphs of CaCO 3 coatings were obtained by variation of growth conditions (time of fiber incubation in work solution, ultrasonic treatment of this system). Coating homogeneity, CaCO 3 polymorphic form, morphology, and CaCO 3 mass can be controlled by number of successive stages of fibrous material treatment. Cytotoxicity tests showed that PCL fibers mineralized with CaCO 3 did not release substances toxic for cells. SEM images of PCL/CaCO 3 scaffolds cultured with cells demonstrate that scaffolds supported cell adhesion and spreading. The presented results show the new technique of controlled PCL scaffold mineralization with vaterite, and an opportunity of using PCL/CaCO 3 as scaffolds for tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 94–103, 2017.