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Titanium dioxide nanoparticle‐induced dysfunction of cardiac hemodynamics is involved in cardiac inflammation in mice
Author(s) -
Hong Fashui,
Wu Nan,
Zhao Xiangyu,
Tian Yusheng,
Zhou Yingjun,
Chen Ting,
Zhai Yanyu,
Ji Li
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35831
Subject(s) - cardiac function curve , inflammation , tumor necrosis factor alpha , socs3 , cytokine , materials science , heart rate , apoptosis , medicine , blood pressure , cardiology , endocrinology , biology , heart failure , biochemistry , stat3
In the past two decades, titanium dioxide nanoparticles (TiO 2 NPs) have been extensively used in medicine, food industry and other daily life, while their possible interactions with the their influence and human body on human health remain not well understood. Thus, the study was designed to examine whether long‐term exposure to TiO 2 NPs cause myocardial dysfunction which is involved in cardiac lesions and alter expression of genes and proteins involving inflammatory response in the mouse heart. The findings showed that intragastric feeding for nine consecutive months with TiO 2 NPs resulted in titanium accumulation, infiltration of inflammatory cells and apoptosis of heart, reductions in net increases of body weight, cardiac indices of function (LV systolic pressure, maximal rate of pressure increase over time, maximal rate of pressure decrease over time and coronary flow), and increases in heart indices, cardiac indices of function (LV end‐diastolic pressure and heart rate) in mice. TiO 2 NPs also decreased ATP production in the hearts. Furthermore, TiO 2 NPs increased expression of nuclear factor‐κB, interleukin‐lβ and tumour necrosis factor‐α, and reduced expression of anti‐inflammatory cytokines including suppressor of cytokine signaling (SOCS) 1 and SOCS3 in the cardiac tissue. These results suggest that TiO 2 NPs may modulate the cardiac function and expression of inflammatory cytokines. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2917–2927, 2016.