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Effect of resorption rate and osteoconductivity of biodegradable calcium phosphate materials on the acquisition of natural bone strength in the repaired bone
Author(s) -
Chiba Shinpei,
Anada Takahisa,
Suzuki Kentaro,
Saito Keisuke,
Shiwaku Yukari,
Miyatake Naohisa,
Baba Kazuyoshi,
Imaizumi Hideki,
Hosaka Masami,
Itoi Eiji,
Suzuki Osamu
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35828
Subject(s) - gelatin , materials science , octacalcium phosphate , biomedical engineering , resorption , biodegradation , artificial bone , bone resorption , composite material , dentistry , calcium , chemistry , metallurgy , medicine , biochemistry , organic chemistry , pathology , biology , genetics
The purpose of this study was to compare the biodegradation rate and quality of regenerated bone among four materials. A short time period of 8 weeks was chosen to examine early bone healing. The rod‐shaped implants of commercially available two β‐tricalcium phosphate (β‐TCP) ceramics with porosity 60% and 71–80%, respectively, laboratory prepared octacalcium phosphate/gelatin composite (OCP/Gel), which has been proven to have a highly osteoconductive and biodegradable property in rat calvarial defect, and gelatin sponge (Gelatin) were implanted in rabbit tibia defect of 6 mm diameter and 7 mm depth for 2, 4 and 8 weeks. Analyses by μCT, histomorphometry and push‐in test were carried out to evaluate the extent of the tissue regeneration and the material biodegradation in the long bone. OCP/Gel and Gelatin were completely resorbed but only OCP/Gel induced cortical bone bridge until 8 weeks that has strength compatible to that of the natural bone. β‐TCP (71%‐80%) and β‐TCP (60%) were not completely resorbed and never induced the amount of new bone formation beyond that by OCP/Gel. The results indicate that the new bone having enough strength could be regenerated if the material shows not only higher biodegradation rate but also higher osteoconductivity. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2833–2842, 2016.