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Fabrication, characterization, and in vitro evaluation of silver‐containing arabinoxylan foams as antimicrobial wound dressing
Author(s) -
Aduba Donald C.,
An SeonSook,
Selders Gretchen S.,
Wang Juan,
Andrew Yeudall W.,
Bowlin Gary L.,
Kitten Todd,
Yang Hu
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35783
Subject(s) - materials science , composite material , swelling , antimicrobial , fabrication , hydrogen peroxide , chemical engineering , organic chemistry , chemistry , medicine , alternative medicine , pathology , engineering
Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze‐drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby‐Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver‐loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2456–2465, 2016.