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Robust and stimuli‐responsive POSS hybrid PDMAEMA hydrogels for controlled drug release
Author(s) -
Chen Yi,
Zeng Guangsheng,
Liu Wenyong
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35771
Subject(s) - materials science , silsesquioxane , swelling , self healing hydrogels , cationic polymerization , chemical engineering , polymerization , ultimate tensile strength , polymer chemistry , drug delivery , composite material , polymer , nanotechnology , engineering
Abstract A new polyhedral oligomeric silsesquioxane (POSS) hybrid hydrogels were desinged and fabricated by introducing cationic octa‐ammonium (Oa)‐POSS) into chemically cross‐linked cationic PDMAEMA hydrogels via in situ radical freezing polymerization. The prepared gels (shorten as OP‐PD gels) show considerably improved properties through the effective incorporation and dispersion of Oa‐POSS particles in gels. Comparing to the Oa‐POSS‐free gels, the hybrid gels own better mechanical properties with higher tensile and compressive strength. Meantime, except the decreased swelling ratio in acid condition, the OP‐PD gels still keep excellent swelling ability with obvious pH and temperature double responsiveness, which is affected by the content of Oa‐POSS slightly. All OP‐PD gels exhibit an ultrarapid deswelling rate due to the interconnected micropores structure caused by freezing and the formation of microhydrophobic region around POSS particles. Moreover, the application potential of OP‐PD gels in drug release was exploited by using flutamide as target drug, the result showed that the increased Oa‐POSS could improve the drug loading ability, and OP‐PD gels showed well controlled‐release effect in simulated human stomachic condition. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2345–2355, 2016.