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Bioactive vapor deposited calcium‐phosphate silica sol–gel particles for directing osteoblast behavior
Author(s) -
Snyder Katherine L.,
Holmes Hallie R.,
McCarthy Connor,
Rajachar Rupak M.
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35746
Subject(s) - materials science , biomaterial , osteoblast , simulated body fluid , chemical vapor deposition , chemical engineering , surface modification , tissue engineering , calcium , nanotechnology , biomedical engineering , composite material , in vitro , scanning electron microscope , biochemistry , metallurgy , chemistry , medicine , engineering
Abstract Silica‐based materials are being developed and used for a variety of applications in orthopedic tissue engineering. In this work, we characterize the ability of a novel silica sol vapor deposition system to quickly modify biomaterial substrates and modulate surface hydrophobicity, surface topography, and composition. We were able to show that surface hydrophobicity, surface roughness, and composition could be rapidly modified. The compositional modification was directed towards generating apatitic‐like surface mineral compositions (Ca/P ratios ∼1.30). Modified substrates were also capable of altering cell proliferation and differentiation behavior of preosteoblasts (MC3T3) and showed potential once optimized to provide a simple means to generate osteo‐conductive substrates for tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2135–2148, 2016.