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Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts
Author(s) -
Lord Megan S.,
Farrugia Brooke L.,
Yan Claudia M. Y.,
Vassie James A.,
Whitelock John M.
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35704
Subject(s) - materials science , reactive oxygen species , cerium oxide , nanoparticle , cd44 , oxygen , cerium , chemical engineering , biophysics , nanotechnology , oxide , microbiology and biotechnology , biochemistry , metallurgy , cell , organic chemistry , biology , chemistry , engineering
Cerium oxide nanoparticles are being widely explored for cell therapies. In this study, nanoceria was functionalized with hyaluronan (HA) using the organosilane linker, 3‐aminopropyltriethoxysilane. HA‐nanoceria was found to be cytocompatible and to reduce intracellular reactive oxygen species in human fibroblasts. The HA‐nanoceria was found to colocalize with CD44 on the surface of the cells and once internalized traffic to the lysosomes, be degraded and induce markers of autophagy. These particles were also effective in reducing the cell surface expression of CD44. Together these data suggest that HA‐nanoceria is a promising drug delivery material to target CD44‐expressing cells through a variety of mechanisms. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1736–1746, 2016.

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