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Long‐term evaluation of the degradation behavior of three apatite‐forming calcium phosphate cements
Author(s) -
An Jie,
Liao Hongbing,
Kucko Nathan W.,
Herber RalfPeter,
Wolke Joop G. C.,
van den Beucken Jeroen J. J. P.,
Jansen John A.,
Leeuwenburgh Sander C. G.
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35641
Subject(s) - apatite , materials science , plga , biocompatibility , calcium , biomedical engineering , degradation (telecommunications) , bone healing , glycolic acid , phosphate , dentistry , chemical engineering , lactic acid , chemistry , nanoparticle , surgery , metallurgy , nanotechnology , medicine , biochemistry , telecommunications , biology , computer science , bacteria , engineering , genetics
Calcium phosphate cements (CPCs) are injectable bone substitutes with a long clinical history because of their biocompatibility and osteoconductivity. Nevertheless, their cohesion upon injection into perfused bone defects as well as their long‐term degradation behavior remain major clinical challenges. Therefore, the long‐term degradation behavior of two types of α‐tricalcium phosphate‐based, apatite‐forming CPCs was compared to a commercially available apatite‐forming cement, that is HydroSet TM . Carboxyl methylcellulose (CMC) was used as cohesion promotor to improve handling properties of the two experimental cements, whereas poly ( d , l ‐lactic‐co‐glycolic) acid (PLGA) microparticles were added to introduce macroporosity and stimulate CPC degradation. All three CPCs were injected into defects drilled into rabbit femoral condyles and explanted after 4, 12, or 26 weeks, after which the bone response was assessed both qualitatively and quantitatively. CPCs without PLGA microparticles degraded only at the periphery of the implants, while the residual CPC volume was close to 90%. On the contrary, bone ingrowth was observed not only at the periphery of the CPC, but also throughout the center of the implants after 26 weeks of implantation for the PLGA‐containing CPCs with a residual CPC volume of approximately 55%. In conclusion, it was shown that CPC containing CMC and PLGA was able to induce partial degradation of apatite‐forming CPCs and concomitant replacement by bone tissue. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1072–1081, 2016.