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Salicylic acid‐based poly(anhydride‐ester) nerve guidance conduits: Impact of localized drug release on nerve regeneration
Author(s) -
Lee Yong S.,
Griffin Jeremy,
Masand Shirley N.,
Shreiber David I.,
Uhrich Kathryn E.
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35630
Subject(s) - regeneration (biology) , materials science , in vivo , nerve guidance conduit , biomedical engineering , drug delivery , scaffold , cytotoxicity , pharmacology , in vitro , microbiology and biotechnology , medicine , chemistry , nanotechnology , biology , biochemistry
Nerve guidance conduits (NGCs) can serve as physical scaffolds aligning and supporting regenerating cells while preventing scar tissue formation that often interferes with the regeneration process. Numerous studies have focused on functionalizing NGCs with neurotrophic factors, for example, to support nerve regeneration over longer gaps, but few directly incorporate therapeutic agents. Herein, we fabricated NGCs from a polyanhydride comprised of salicylic acid (SA), a nonsteroidal anti‐inflammatory drug, then performed in vitro and in vivo assays. In vitro studies included cytotoxicity, anti‐inflammatory response, and NGC porosity measurements. To prepare for implantation, type I collagen hydrogels were used as NGC luminal fillers to further enhance the axonal regeneration process. For the in vivo studies, SA‐NGCs were implanted in femoral nerves of mice for 16 weeks and evaluated for functional recovery. The SA‐based NGCs functioned as both a drug delivery vehicle capable of reducing inflammation and scar tissue formation because of SA release as well as a tissue scaffold that promotes peripheral nerve regeneration and functional recovery. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 975–982, 2016.