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Proliferative activity of elastin‐like‐peptides depends on charge and phase transition
Author(s) -
Yuan Yuan,
Koria Piyush
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35609
Subject(s) - materials science , elastin , fibroblast , regeneration (biology) , biocompatibility , merge (version control) , biophysics , biomedical engineering , scaffold , nanotechnology , microbiology and biotechnology , biochemistry , chemistry , biology , computer science , in vitro , medicine , genetics , information retrieval , metallurgy
Elastin‐like‐peptides (ELPs) are stimulus‐responsive protein‐based polymers and are attractive biomaterials due to their biocompatibility and unique properties. This study shows that in addition to their physical properties, ELPs have biological activities that are conducive to tissue regeneration. Specifically, we found that ELPs induce fibroblast proliferation via cell surface heparan sulfate proteoglycans (HSPG). Furthermore, our data suggests that ELP based materials with differential proliferative potential can be designed by controlling the interaction of ELPs with HSPGs by incorporating either hydrophobic or positively charged residues within the ELP sequence. Fibroblast proliferation is important for granulation tissue formation which is important in chronic wounds as well as in healing of other tissues. The customizable biological activity of ELPs coupled with their unique physical properties will enable us to design novel, sustainable and cost effective therapies for different tissue regeneration applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 697–706, 2016.