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Synthesis of self‐assembled IL‐1Ra‐presenting nanoparticles for the treatment of osteoarthritis
Author(s) -
Agarwal Rachit,
Volkmer Tiago M.,
Wang Peiyi,
Lee L. Andrew,
Wang Qian,
García Andrés J.
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35601
Subject(s) - materials science , osteoarthritis , inflammation , cartilage , nanoparticle , receptor antagonist , interleukin 1 receptor antagonist , biomedical engineering , cancer research , medicine , nanotechnology , antagonist , receptor , pathology , alternative medicine , anatomy
Osteoarthritis is a progressive joint disease that results in degradation of cartilage in load‐bearing joints. Pain and inflammation in the joint are the hallmarks of this condition, which further exacerbate the cartilage destruction and health of the patient. It is hence imperative to treat the joint inflammation at the earliest. Interleukin 1 (IL‐1) blockade by IL‐1 receptor antagonist (IL‐1Ra) has shown promise in the clinic but this therapy suffers from rapid clearance, high doses, and frequent intervention. Use of carrier particles that result in longer residence time has been proposed. Here we have synthesized a new class of nanoparticles presenting IL‐1Ra on the surface and with tunable size from 300 to 700 nm. These IL‐1Ra‐poly(2‐hydroxyethyl methacrylate)‐pyridine nanoparticles are cytocompatible and stable in serum‐containing solutions for several days. Our results further demonstrate that these nanoparticles are capable of blocking IL‐1β signaling in an NF‐κB inducible reporter cell line. These engineered nanoparticles are promising for localized intra‐articular delivery in joint space to reduce inflammation in osteoarthritis and other inflammatory diseases. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 595–599, 2016.