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New guanidine‐containing nanocomposites impeding the growth of Staphylococcus epidermidis 33 and the biofilm formation
Author(s) -
Gorbunova Marina,
Lemkina Larisa
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35596
Subject(s) - materials science , staphylococcus epidermidis , biofilm , guanidine , nanocomposite , microbiology and biotechnology , chemical engineering , nanotechnology , staphylococcus aureus , biology , bacteria , biochemistry , engineering , genetics
New water‐soluble nanocomposites (AgNCs) based on Ag and copolymers of 2,2‐diallyl‐1,1,3,3‐tetraethylguanidiniumchloride with N ‐vinylpyrrolidone [poly(AGC‐VP)] and vinylacetate [poly(AGC‐VA)] have been developed. Antibacterial action of new silver nanocomposites on S. epidermidis 33 (planctonic cells and biofilms) is reported in this study. AgNCs strongly inhibited biofilms formation of S. epidermidis 33 . The viability of S. epidermidis 33 cells in biofilms was considerably reduced by new AgNCs. It has been shown that S. epidermidis 33 inactivation in biofilms occurs at AgNC concentrations > 5 times higher as compared to those inhibiting completely the planktonic cells. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 630–638, 2016.