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Calcium carbonate hydrogel construct with cynnamaldehyde incorporated to control inflammation during surgical procedure
Author(s) -
Dewi Anne Handrini,
Ana Ika Dewi,
Jansen John
Publication year - 2016
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35571
Subject(s) - cinnamaldehyde , swelling , materials science , ultimate tensile strength , self healing hydrogels , in vivo , biomedical engineering , chemical engineering , polymer chemistry , chemistry , organic chemistry , composite material , medicine , microbiology and biotechnology , biology , catalysis , engineering
The incorporation of CaCO 3 hydrogel has been proven to enhance the bone biological activity of Plaster of Paris (POP) and to decrease its degradability. However, the installation of this bone substitute in a bone defect will still be associated with an inflammatory response. In this study, the influence of cinnamaldehyde as anti‐inflammatory agent, was investigated. In addition, it is known that aldehyde chains of cinnamaldehyde may also act as crosslinking agent and function as a plastisizer to the CaCO 3 hydrogel construct. Therefore, different concentrations of cinnamaldehyde were added to CaCO 3 hydrogel and the effect on the diametral tensile strength, age swelling, gel fractination, cinnamaldehyde release, antimicrobial effect, and cell cytotoxycity were investigated. The incorporation of cinnamaldehyde was found to decrease the age swelling and degradation rate of CaCO 3 hydrogel and to have no toxic effect to human gingival fibroblast cells. Moreover, the incorporation of cinnamaldehyde essential oil into the CaCO 3 hydrogel was beneficial and acted as an antiinflammatory agent. Further research in vivo is warranted to determine the final favorable effect of cinnamaldehyde incorporated CaCO 3 hydrogel in POP to provide a bone substitute. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 768–774, 2016.