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Alkalization is responsible for antibacterial effects of corroding magnesium
Author(s) -
Rahim Muhammad Imran,
Eifler Rainer,
Rais Bushra,
Mueller Peter P.
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35503
Subject(s) - magnesium , corrosion , antibacterial activity , materials science , bacteria , metal , antibiotics , nuclear chemistry , aqueous solution , metal ions in aqueous solution , microbiology and biotechnology , metallurgy , chemistry , biology , organic chemistry , genetics
Magnesium alloys are presently investigated as potential medical implant materials for temporary applications. Magnesium has been reported to have antibacterial activities and could therefore be used to prevent antibiotic treatment‐resistant bacterial implant infections. For characterizing the effects of magnesium on infectious bacteria, bioluminescent S. aureus or P. aeruginosa were employed. The proliferation of both types of bacteria was suppressed in the presence of metallic magnesium and also in aqueous magnesium corrosion extracts. Of the two soluble corrosion products, magnesium ions were well tolerated while antibacterial activities correlated with increased pH levels of the supernatants. The alkaline pH alone was sufficient for the antibacterial effects which were completely abolished when the pH of the corrosion supernatants was neutralized. These results demonstrate that pH increases are necessary and sufficient for the antibacterial activity of metallic magnesium. In an animal model magnesium implants showed an enhanced but variable resistance to bacterial colonization. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3526–3532, 2015.