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A quantitative approach for studying the bioactivity of nanohydroxyapatite/gold composites
Author(s) -
Mostafa Amany A.,
Oudadesse Hassane,
ElSayed Mayyada M. H.
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35494
Subject(s) - nanocomposite , materials science , thermogravimetric analysis , fourier transform infrared spectroscopy , diffusion , chemical engineering , polyvinyl alcohol , sorption , composite material , thermogravimetry , transmission electron microscopy , apatite , differential thermal analysis , simulated body fluid , scanning electron microscope , nanotechnology , organic chemistry , chemistry , adsorption , physics , engineering , thermodynamics , optics , diffraction
This work describes a quantitative kinetic approach to assess the in vitro bioactivity of gold‐doped hydroxyapatite‐polyvinyl alcohol nanocomposites. The surface morphology of the in situ prepared nanocomposites as characterized by transmission electron microscopy (TEM) revealed a rod‐like shape. Differential thermal analysis‐thermogravimetric (DTA–TG), and fourier transformed infrared spectroscopy (FTIR) as well as zeta potential measurements of the prepared nanocomposites were carried out. Uptake profiles of Ca and P were studied onto nanocomposites of different gold concentrations after their soaking in simulated body fluid and they best followed the pseudo second‐order kinetic model. The highest uptakes of both Ca and P were obtained using the nanocomposite with the lowest concentration of gold. Furthermore, sorption mechanism was described by the intraparticle diffusion model where pore diffusion was found to be the rate limiting step. The prepared nanocomposites have promising potential in orthopedic and tissue engineering applications because of their high capacity and fast uptake for Ca and P, which form apatite. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3483–3492, 2015.