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Scaffold materials from glycosylated and PEGylated bovine serum albumin
Author(s) -
Wang Kai,
David Allan E.,
Choi YoungSuk,
Wu Yonnie,
BuschleDiller Gisela
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35430
Subject(s) - materials science , bovine serum albumin , scaffold , biomedical engineering , chemical engineering , biochemistry , biology , medicine , engineering
Bovine serum albumin has been PEGylated and glycosylated to create mimetic materials for the extracellular matrix (ECM) with potential tissue engineering applications. Different surfaces for cell adhesion were achieved by crosslinking the initial albumin product and forming either a coating or a sponge‐like three‐dimensional morphology to mimic the mesh structure of natural ECM. The biocompatibility of the albumin matrix with mammalian cells was evaluated using cell culture assays with NIH 3T3 cells. The results indicated that glycoprotein composition and specific morphology of the assembly can improve the cell growth environment. These ECM mimetic structures might eventually be considered to serve as alternatives for the more expensive collagen and elastin based ECM substances currently in use in tissue engineering. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2839–2846, 2015.