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In vitro comparative survey of cell adhesion and proliferation of human induced pluripotent stem cells on surfaces of polymeric electrospun nanofibrous and solution‐cast film scaffolds
Author(s) -
Hoveizi Elham,
EbrahimiBarough Somayeh,
Tavakol Shima,
Nabiuni Mohammad
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35420
Subject(s) - materials science , extracellular matrix , polycaprolactone , scaffold , cell adhesion , adhesion , morphogenesis , microbiology and biotechnology , in vitro , cell growth , tissue engineering , induced pluripotent stem cell , human induced pluripotent stem cells , nanotechnology , biomedical engineering , chemistry , composite material , biology , polymer , biochemistry , embryonic stem cell , gene , medicine
Extracellular matrix (ECM) components play a critical role in regulating cell behaviors. Interactions between ECM components and cells are important in various biological processes, including cell attachment, survival, morphogenesis, spreading, proliferation, and gene expression. In this study the in vitro responses of human induced pluripotent stem cells (hiPSCs) on polycaprolactone (PCL) electrospun nanofibrous scaffold were reported in comparison with those of the cells on corresponding solution‐cast film scaffold. Our results demonstrated that the nanofibrous scaffold showed better support for the attachment and proliferation of hiPSCs than their corresponding film scaffold. Consequently, we emphasize that hiPSCs can sense the physical properties and chemical composition of the materials and regulate their behaviors accordingly. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2952–2958, 2015.