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A ferulic acid (FA)‐eluting system for biodegradable magnesium stent: C ells response of HUVECs
Author(s) -
Zhang Erlin,
Shen Feng
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35410
Subject(s) - ferulic acid , biocompatibility , materials science , cell adhesion , adhesion , viability assay , cell growth , drug delivery , ultimate tensile strength , nuclear chemistry , pharmacology , biophysics , biochemistry , chemistry , cell , nanotechnology , composite material , medicine , biology , metallurgy
A new drug‐eluting system was designed for biodegradable magnesium stents, in which ferulic acid (FA) was used as drug due to its promotion function to endothelial cells and PHBHHx as drug delivery due to its biodegradability and biocompatibility. A 5 and 10% FA were added in PHBHHx to prepare FA containing PHBHHX films. The cell adhesion, spreading and proliferation on these films was investigated in order to assess cell response of HUVECs. It was also found that FA enhanced the adhesion, spreading and proliferation of HUVECs in a dose‐dependent manner. Cell viability after H 2 O 2 injury and NO production of HUVECs were also studied. The results indicated that FA effectively inhibited H 2 O 2 ‐induced injury and promotes NO production. It was also shown that alkali treatment improved the cell adhesion, spreading and proliferation while the treatment reduces the FA release and in turn reduces the inhibition on H 2 O 2 ‐induced injury and NO production. However, alkali treatment itself had no influence on the H 2 O 2 induced injure and NO production. The tensile shear strength between the FA containing coating and Mg substrate was also tested. All results demonstrated that FA containing PHBHHx films exhibited strong promotion to the endothelialization and could be a choice for surface modification of magnesium stent. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2758–2769, 2015.