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Magnetic nanoparticles‐loaded PLA/PEG microspheres as drug carriers
Author(s) -
Frounchi Masoud,
Shamshiri Soodeh
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35317
Subject(s) - materials science , ethylene glycol , nanoparticle , plasticizer , drug delivery , drug carrier , doxorubicin hydrochloride , nuclear chemistry , polylactic acid , peg ratio , magnetite , chemical engineering , nanotechnology , polymer , composite material , doxorubicin , chemistry , medicine , surgery , finance , chemotherapy , engineering , economics , metallurgy
Surface‐modified magnetite (Fe 3 O 4 ) nanoparticles with an average size of 22 nm were prepared. The nanoparticles had a saturation magnetization of 50.7 emu g −1 . Then magnetite and drug‐loaded microspheres of poly (lactic acid)/poly (ethylene glycol) were prepared at various compositions. The microspheres were spherical in shape and had smooth surface. The diameter size of the microspheres ranged between about 0.2 and 4 μm. Doxorubicin hydrochloride for cancer treatment was the drug that loaded into the microspheres. The prepared microspheres were characterized by FTIR, XRD, VSM, SEM and drug‐release measurements. It was found that the drug cumulative release percentage was proportional to (time) n where 0.61 < n < 0.75 depending on PEG and Fe 3 O 4 contents. The drug release was controlled through a combination of diffusion and PLA hydrolysis and obeyed a non‐fickian mechanism. The drug release was facilitated by presence of poly (ethylene glycol) as PLA plasticizer and was higher under applied external magnetic field. The obtained magnetic microspheres could be used as drug carriers for targeted drug delivery purposes. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1893–1898, 2015.