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A dual‐task design of corrosion‐controlling and osteo‐compatible hexamethylenediaminetetrakis‐ (methylene phosphonic acid) (HDTMPA) coating on magnesium for biodegradable bone implants application
Author(s) -
Zhao Sheng,
Chen Yingqi,
Liu Bo,
Chen Meiyun,
Mao Jinlong,
He Hairuo,
Zhao Yuancong,
Huang Nan,
Wan Guojiang
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35301
Subject(s) - materials science , corrosion , coating , magnesium , apatite , chemical engineering , chelation , surface modification , simulated body fluid , nuclear chemistry , metallurgy , composite material , scanning electron microscope , chemistry , engineering
Magnesium as well as its alloys appears increasingly as a revolutionary bio‐metal for biodegradable implants application but the biggest challenges exist in its too fast bio‐corrosion/degradation. Both corrosion‐controllable and bio‐compatible Mg‐based bio‐metal is highly desirable in clinic. In present work, hexamethylenediaminetetrakis (methylenephosphonic acid) [HDTMPA, (H 2 O 3 P−CH 2 ) 2 −N−(CH 2 ) 6 −N−(CH 2 −PO 3 H 2 ) 2 ], as a natural and bioactive organic substance, was covalently immobilized and chelating‐deposited onto Mg surface by means of chemical conversion process and dip‐coating method, to fullfill dual‐task performance of corrosion‐protective and osteo‐compatible functionalities. The chemical grafting of HDTMPA molecules, by participation of functional groups on pretreated Mg surface, ensured a firmly anchored base layer, and then sub‐sequential chelating reactions of HDTMPA molecules guaranteed a homogenous and dense HDTMPA coating deposition on Mg substrate. Electrochemical corrosion and immersion degradation results reveal that the HDTMPA coated Mg provides a significantly better controlled bio‐corrosion/degradation behavior in phosphate buffer saline solution as compared with untreated Mg from perspective of clinic requirement. Moreover, the HDTMPA coated Mg exhibits osteo‐compatible in that it induces not only bioactivity of bone‐like apatite precipitation but also promotes osteoblast cells adhesion and proliferation. Our well‐controlled biodegradable and biocompatible HDTMPA modified Mg might bode well for next generation bone implant application. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1640–1652, 2015.