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Microporous calcium phosphate ceramics driving osteogenesis through surface architecture
Author(s) -
Zhang Jingwei,
Barbieri Davide,
ten Hoopen Hetty,
de Bruijn Joost D.,
van Blitterswijk Clemens A.,
Yuan Huipin
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35272
Subject(s) - microporous material , materials science , ceramic , phosphate , calcium , adsorption , mineralization (soil science) , biomedical engineering , composite material , mineralogy , chemistry , metallurgy , biochemistry , organic chemistry , nitrogen , medicine
The presence of micropores in calcium phosphate (CaP) ceramics has shown its important role in initiating inductive bone formation in ectopic sites. To investigate how microporous CaP ceramics trigger osteoinduction, we optimized two biphasic CaP ceramics (i.e., BCP‐R and BCP‐S) to have the same chemical composition, equivalent surface area per volume, comparable protein adsorption, similar ion (i.e., calcium and phosphate) exchange and the same surface mineralization potential, but different surface architecture. In particular, BCP‐R had a surface roughness (Ra) of 325.4 ± 58.9 nm while for BCP‐S it was 231.6 ± 35.7 nm. Ceramic blocks with crossing or noncrossing channels of 250, 500, 1000, and 2000 µm were implanted in paraspinal muscle of dogs for 12 weeks. The percentage of bone volume in the channels was not affected by the type of pores (i.e., crossing vs. closed) or their size, but it was greatly influenced by the ceramic type (i.e., BCP‐R vs. BCP‐S). Significantly, more bone was formed in the channels of BCP‐R than in those of BCP‐S. Since the two CaP ceramics differed only in their surface architecture, the results hereby demonstrate that microporous CaP ceramics may induce ectopic osteogenesis through surface architecture. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1188–1199, 2015.