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A novel pH‐responsive interpolyelectrolyte hydrogel complex for the oral delivery of levodopa. Part II: Characterization and formulation of an IPEC‐based tablet matrix
Author(s) -
Ngwuluka Ndidi C.,
Choonara Yahya E.,
Kumar Pradeep,
du Toit Lisa C.,
Khan Riaz A.,
Pillay Viness
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35258
Subject(s) - materials science , differential scanning calorimetry , fourier transform infrared spectroscopy , drug delivery , biomedical engineering , polymer , biomaterial , chemical engineering , matrix (chemical analysis) , scanning electron microscope , nuclear chemistry , composite material , nanotechnology , chemistry , medicine , physics , engineering , thermodynamics
This study was undertaken in order to apply a synthesized interpolyelectrolyte complex (IPEC) of polymethacrylate and carboxymethylcellulose as a controlled release oral tablet matrix for the delivery of the model neuroactive drug levodopa. The IPEC (synthesized in Part I of this work) was characterized by techniques such as Fourier Transform Infra‐Red (FTIR) spectroscopy, Differential Scanning Calorimetry (DSC), Advanced DSC (ADSC), and Scanning Electron Microscopy (SEM). The tablet matrices were formulated and characterized for their drug delivery properties and in vitro drug release. FTIR confirmed the interaction between the two polymers. The IPEC composite generated tablet matrices with a hardness ranging from 19.152–27.590 N /mm and a matrix resilience ranging between 42 and 46%. An IPEC of polymethacrylate and carboxymethylcellulose was indeed an improvement on the inherent properties of the native polymers providing a biomaterial with the ability to release poorly soluble drugs such as levodopa at a constant rate over a prolonged period of time. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1085–1094, 2015.