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Multiwalled carbon nanotube‐modified poly( d , l ‐lactide‐ co ‐glycolide) scaffolds for dendritic cell load
Author(s) -
Yang Yanzhu,
Shi Sanyuan,
Ding Qian,
Chen Jian,
Peng Jinliang,
Xu Yuhong
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35255
Subject(s) - materials science , plga , biocompatibility , scaffold , surface modification , tissue engineering , nanotechnology , carbon nanotube , chemical engineering , biomedical engineering , nanoparticle , metallurgy , medicine , engineering
Abstract Poly( d , l ‐lactide‐ co ‐glycolide) (PLGA) is widely used in a variety of tissue engineering and drug delivery applications due to its biodegradability and biocompatibility. But PLGA surfaces are usually hydrophobic which limited the loading and seeding capacities for cells, especially semiadherent immune cells. In this paper we described an attempt to improve the hydrophilicity and surface architecture for accommodating dendritic cells (DCs) that are widely used as professional antigen presenting cells in immune therapy of cancer and other diseases. The 3D porous PLGA scaffold was made by solvent casting/salt leaching of PLGA blended with surface functionalized multiwalled carbon nanotubes (F‐MWCNTs). The incorporation and dispersion of F‐MWCNT in the scaffold structures resulted in not only improved surface hydrophilicity but also nanoscale surface structure that would provide a preferable microenvironment for DCs attachment. We think such a scaffold material may be more desirable for immune cell delivery for immunotherapy. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1045–1052, 2015.