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Stem cell responses to nanotopography
Author(s) -
Park Siyeon,
Im GunIl
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35236
Subject(s) - nanotopography , materials science , nanotechnology , cell , microbiology and biotechnology , regeneration (biology) , biology , genetics
Abstract Cells interact with various nanoscaled topographical and biochemical cues in their cellular macromolecular environment. Nanotopography recreates or mimic the cellular macromolecular environment in vitro . The influence of material surface topography on the behavior of adherent cells has been studied. Current techniques enable various kinds of nanopatterned surface to be generated and applied to cells. The purpose of this review is to provide an overview of nanotopography and its surface patterns, and introduce nanotopography effects on cell behavior including cell attachment, proliferation, and cell differentiation with particular emphasis on musculoskeletal regeneration. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1238–1245, 2015.