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Investigating the solubility and cytocompatibility of CaO–Na 2 O–SiO 2 /TiO 2 bioactive glasses
Author(s) -
Wren Anthony W.,
Coughlan Aisling,
Smith Courtney M.,
Hudson Sarah P.,
Laffir Fathima R.,
Towler Mark R.
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35223
Subject(s) - materials science , solubility , particle size , titanium , bioactive glass , nuclear chemistry , calcium , chemical engineering , mineralogy , population , composite material , metallurgy , organic chemistry , chemistry , demography , sociology , engineering
Abstract This study aims to investigate the solubility of a series of titanium (TiO 2 )‐containing bioactive glasses and their subsequent effect on cell viability. Five glasses were synthesized in the composition range SiO 2 –Na 2 O–CaO with 5 mol % of increments TiO 2 substituted for SiO 2 . Glass solubility was investigated with respect to (1) exposed surface area, (2) particle size, (3) incubation time, and (4) compositional effects. Ion release profiles showed that sodium (Na + ) presented high release rates after 1 day and were unchanged between 7 and 14 days. Calcium (Ca 2+ ) release presented a significant change at each time period and was also composition dependent, where a reduction in Ca 2+ release is observed with an increase in TiO 2 concentration. Silica (Si 4+ ) release did not present any clear trends while no titanium (Ti 4+ ) was released. Cell numbers were found to increase up to 44%, compared to the growing control population, with a reduction in particle size and with the inclusion of TiO 2 in the glass composition. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 709–720, 2015.