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Preliminary investigation on hemocompatibility of poly(vinylidene fluoride) membrane grafted with acryloylmorpholine via ATRP
Author(s) -
Shen Xiang,
Liu Jie,
Feng Xia,
Zhao Yiping,
Chen Li
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35213
Subject(s) - materials science , atom transfer radical polymerization , membrane , contact angle , copolymer , phase inversion , polymer chemistry , protein adsorption , adsorption , chemical engineering , grafting , amphiphile , polymer , composite material , organic chemistry , chemistry , biochemistry , engineering
This work provides a promising way to improve the hemocompatibility of PVDF membrane. An amphiphilic copolymer (PVDF ‐g‐ PACMO) having PVDF backbones and poly( N ‐acryloylmorpholine) (PACMO) side chains was synthesized via atom transfer radical polymerization (ATRP). It is found that the grafting degree of the PACMO increases linearly with the increase of ACMO concentration in the reaction solution. The PVDF ‐g‐ PACMO membrane was prepared via immersed phase inversion method. The structure and performances were evaluated by X‐ray photoelectron spectroscopy, field emission scanning electron microscopy, water contact angle, and filtration experiment. The hemocompatibility of the membranes were preliminarily investigated by protein adsorption, platelet adhesion, anticoagulant evaluation and hemolysis test. The results indicate that the PVDF membrane functionalized by PACMO can suppress the protein adsorption and platelet adhesion, and shows an improved hemocompatibility. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 683–692, 2015.