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The cell‐engineered construct of cartilage on the basis of biopolymer hydrogel matrix and human adipose tissue‐derived mesenchymal stromal cells (in vitro study)
Author(s) -
Surguchenko Valentina A.,
Ponomareva Anna S.,
Kirsanova Ljudmila A.,
Skaleckij Nikolaj N.,
Sevastianov Viktor I.
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35197
Subject(s) - mesenchymal stem cell , materials science , extracellular matrix , biopolymer , adipose tissue , matrix (chemical analysis) , chondrogenesis , cartilage , stromal cell , biomedical engineering , glycosaminoglycan , in vitro , tissue engineering , microbiology and biotechnology , anatomy , polymer , composite material , chemistry , biology , biochemistry , medicine , cancer research
Abstract The study results of in vitro formation of tissue‐engineered cartilage construct on the basis of cell‐engineered construct composed of biopolymer hydrogel matrix and human adipose tissue‐derived mesenchymal stromal cells (hADSCs) are presented. It was revealed that hADSCs in biopolymer hydrogel matrix Sphero ®GEL under chondrogenic conditions generate three‐dimensional structures and produce cartilaginous extracellular matrix components: collagen type II and glycosaminoglycans. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 463–470, 2015.