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Silicon calcium phosphate ceramic as novel biomaterial to simulate the bone regenerative properties of autologous bone
Author(s) -
Manchón A.,
Alkhraisat M.,
RuedaRodriguez C.,
Torres J.,
PradosFrutos J. C.,
Ewald A.,
Gbureck U.,
CabrejosAzama J.,
RodriguezGonzález A.,
LópezCabarcos E.
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35196
Subject(s) - materials science , biomaterial , ceramic , calcium , bone healing , biomedical engineering , osteoblast , phosphate , bone mineral , composite material , nanotechnology , metallurgy , anatomy , chemistry , biochemistry , osteoporosis , pathology , in vitro , medicine
This study was conducted to develop novel ceramic bone substitute that resembles the autologous bone behavior when used as graft material. Solid‐state reaction at 1100°C was performed to synthesize β‐tricalcium phosphate (β‐TCP) and biphasic calcium phosphate (BCP). The ceramics were further analyzed to characterize phase composition, microstructural properties, cytocompatability and then challenged to regenerate critical bone defects in the parietal bone of rabbits. X‐ray diffraction analysis confirmed the production of β‐TCP and indicated the synthesis of novel BCP composed of β‐TCP and silicocarnotite (calcium phosphate silicate mineral). The cytocompatibility test with human osteoblast cell line revealed enhanced cell proliferation on the BCP ceramic. The novel BCP induced the filling of about 73% of the bone defect with a newly formed bone tissue and an almost complete degradation after 12 weeks of healing. This novel ceramic resembles the autologous bone properties of complete degradation and efficient enhancement of bone formation, making it promising as bone graft material. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 479–488, 2015.