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Effects of antibacterial nanostructured composite films on vascular stents: Hemodynamic behaviors, microstructural characteristics, and biomechanical properties
Author(s) -
Cheng HanYi,
Hsiao WenTien,
Lin LiHsiang,
Hsu YaJu,
Sinrang Andi Wardihan,
Ou KengLiang
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35172
Subject(s) - materials science , composite number , restenosis , stent , transmission electron microscopy , composite material , biomedical engineering , stress (linguistics) , finite element method , blood flow , nanotechnology , surgery , structural engineering , radiology , medicine , linguistics , philosophy , engineering
The purpose of this research was to investigate stresses resulting from different thicknesses and compositions of hydrogenated Cu‐incorporated diamond‐like carbon (a‐C:H/Cu) films at the interface between vascular stent and the artery using three‐dimensional reversed finite element models (FEMs). Blood flow velocity variation in vessels with plaques was examined by angiography, and the a‐C:H/Cu films were characterized by transmission electron microscopy to analyze surface morphology. FEMs were constructed using a computer‐aided reverse design system, and the effects of antibacterial nanostructured composite films in the stress field were investigated. The maximum stress in the vascular stent occurred at the intersections of net‐like structures. Data analysis indicated that the stress decreased by 15% in vascular stents with antibacterial nanostructured composite films compared to the control group, and the stress decreased with increasing film thickness. The present results confirmed that antibacterial nanostructured composite films improve the biomechanical properties of vascular stents and release abnormal stress to prevent restenosis. The results of the present study offer the clinical benefit of inducing superior biomechanical behavior in vascular stents. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 269–275, 2015.