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Preparation and in vivo evaluation of multifunctional 90 Y‐labeled magnetic nanoparticles designed for cancer therapy
Author(s) -
Radović Magdalena,
Calatayud María Pilar,
Goya Gerardo Fabián,
Ibarra Manuel Ricardo,
Antić Bratislav,
Spasojević Vojislav,
Nikolić Nadežda,
Janković Drina,
Mirković Marija,
VranješĐurić Sanja
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35160
Subject(s) - biodistribution , materials science , in vivo , magnetic nanoparticles , nanoparticle , polyethylene glycol , radionuclide therapy , peg ratio , nuclear chemistry , radiochemistry , biomedical engineering , nanotechnology , nuclear medicine , chemistry , organic chemistry , medicine , microbiology and biotechnology , finance , economics , biology
Two different types of magnetic nanoparticles (MNPs) were synthesized in order to compare their efficiency as radioactive vectors, Fe 3 O 4 ‐Naked (80 ± 5 nm) and polyethylene glycol 600 diacid functionalized Fe 3 O 4 (Fe 3 O 4 ‐PEG600) MNPs (46 ± 0.6 nm). They were characterized based on the external morphology, size distribution, and colloidal and magnetic properties. The obtained specific power absorption value for Fe 3 O 4 ‐PEG600 MNPs was 200 W/g, indicated their potential in hyperthermia based cancer treatments. The labeling yield, in vitro stability and in vivo biodistribution profile of 90 Y‐MNPs were compared. Both types of MNPs were 90 Y‐labeled in reproducible high yield (>97%). The stability of the obtained radioactive nanoparticles was evaluated in saline and human serum media in order to optimize the formulations for in vivo use. The biodistribution in Wistar rats showed different pharmacokinetic behaviors of nanoparticles: a large fraction of both injected MNPs ended in the liver (14.58%ID/g for 90 Y‐Fe 3 O 4 ‐Naked MNPs and 19.61%ID/g for 90 Y‐Fe 3 O 4 ‐PEG600 MNPs) whereas minor fractions attained in other organs. The main difference between the two types of MNPs was the higher accumulation of 90 Y‐Fe 3 O 4 ‐Naked MNPs in the lungs (12.14%ID/g vs. 2.00%ID/g for 90 Y‐Fe 3 O 4 ‐PEG600 MNPs) due to their in vivo agglomeration. The studied radiolabeled magnetic complexes such as 90 Y‐Fe 3 O 4 ‐PEG600 MNPs constitute a great promise for multiple diagnostic‐therapeutic uses combining, for example, MRI‐magnetic hyperthermia and regional radiotherapy. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 126–134, 2015.