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Bone tissue engineering and regenerative medicine: Targeting pathological fractures
Author(s) -
Nguyen Duong T.,
Burg Karen J. L.
Publication year - 2015
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.35139
Subject(s) - nonunion , bone healing , regenerative medicine , reduction (mathematics) , medicine , bone fracture , fragility fracture , regeneration (biology) , dentistry , materials science , osteoporosis , surgery , stem cell , pathology , radiology , biology , genetics , geometry , mathematics , bone mineral , microbiology and biotechnology
Patients with bone diseases have the highest risk of sustaining fractures and of suffering from nonunion bone healing due to tissue degeneration. Current fracture management strategies are limited in design and functionality and do not effectively promote bone healing within a diseased bone environment. Fracture management approaches include pharmaceutical therapy, surgical intervention, and tissue regeneration for fracture prevention, fracture stabilization, and fracture site regeneration, respectively. However, these strategies fail to accommodate the pathological nature of fragility fractures, leading to unwanted side effects, implant failures, and nonunions. To target fragility fractures, fracture management strategies should include bioactive bone substitutes designed for the pathological environment. However, the clinical outcome of these materials must be predictable within various disease environments. Initial development of a targeted treatment strategy should focus on simulating the physiological in vitro bone environment to predict clinical effectiveness of the engineered bone. An in vitro test system can facilitate reduction of implant failures and non‐unions in fragility fractures. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A : 103A: 420–429, 2015.